Harlan Teklad TD.01432
Fenbendazole is added to Harlan Teklad Global 18% Protein Rodent Diet at 150 mg/kg to produce Harlan Teklad TD.01432. This diet may be used as an effective treatment for pinworm infections which are still commonly found in populations of rats, mice and other rodent species used for biomedical research. Administering medication through diet ensures proper dosing, prevents missed treatments and reduces labor costs compared to other methods.

Directions
The diet contains 150 ppm fenbendazole to ensure a
minimum dose of 8 mg/kg body weight. Irradiated diet may be fed to both mice and rats, but autoclaved diet only to mice. There is significant destruction of fenbendazole during autoclaving which could result in inadequate dosing of rats that consume less diet per unit of body weight compared to mice.⁴

The medicated diet is typically fed for seven consecutive days followed by an additional seven consecutive days on the regular nonmedicated diet. This should be repeated for a minimum of three cycles (minimum 42 days).² Environmental decontamination does not appear to be essential for successful eradication of pinworms.^1,3

References
1. Hauerkamp MJ, Benjamin KA, Webb SK, Pullium JK. Long-term results of dietary fenbendazole to eradicate
Syphacia muris from rat colonies. Contemp. Top. Lab. Anim. Sci. 2004; 43 (2):35-36.
2. Pritchett KR, Johnston NA. A review of treatments for the eradication of pinworm infections from laboratory rodent
colonies. Contemp. Top. Lab. Anim. Sci 2002; 41(2):36-44.
3. Hauerkamp MJ, Benjamin KA, Zitzow LA, Pullium JK, Lloyd JA, Thompson WD, Webb SK, Lehner NDM. Fenbendazole treatment without environmental decontamination eradicates Syphacia muris from all rats in a large, complex research institution. Contemp. Top. Lab. Anim. Sci. 2000; 39 (3):9-12.
4. Coghlan L.G., Lee DR, Psencik B, Weiss D. Practical and effective eradication of pinworms (Syphacia muris) in rats by use of fenbendazole. Lab. Anim. Sci. 1993; 43 (5):481-487.